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What is Tramadol?
Tramadol is an opioid that's used medicinally for pain management and has been researched for many other uses. It's also gained a place in recreational use. It has a more complex pharmacology than a lot of opioids.
The effects of a drug will vary for each user. So, the most I can offer is a general overview of the effects. Among the positive effects are pain relief, euphoria, reduced anxiety, sedation and a general sense of well-being. The negative effects can include dry mouth, dizziness, nausea, vomiting, anxiety, constipation, difficulty urinating, drowsiness and headache.
Tramadol euphoria is generally less intense than what's seen with morphine or heroin. Though, it can still provide a notable amount of cognitive and physical euphoria such as feelings of warmth, love, and comfort. It's also less sedating than other common opioids and is less likely to cause constipation.
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Orally it lasts for six to twelve hours. It has an onset of 45 to 90 minutes and is strongest 2 to 6 hours after administration. With the onset, it's possible to feel effects a bit earlier, but it does have a slow onset overall.
Tramadol is a synthetic opioid which also functions as an SNRI. It has a complex from ecology relative to many opioids, which is why opioid antagonists and inverse agonists don't fully reverse it.
The R and S isomers of Tramadol are sold together as a racemic mixture since each provides different, but useful effects.
Its metabolite is a core part of Tramadol from ecology, which means individual metabolic differences can result in markedly different effects per dose.
Tramadol is an MU opioid agonist and it also inhibits the reuptake of serotonin. Some reports have suggested it could release serotonin as well. Further, it's a norepinephrine reuptake inhibitor, which makes it an SNRI standing for serotonin-norepinephrine reuptake inhibitor.
The MU opioid and SNRI actions are responsible for much of what Tramadol does, but its pharmacology doesn't end there. It also has some NMDA antagonist, 5-HT2C antagonist, nicotinic acetylcholine antagonist and muscarinic acetylcholine antagonist properties.
Tramadol is well-known seizure threshold lowering effect may at least partially come from 5-HT2C antagonism.
Moving to Tramadol metabolite O-desmethyl tramadol there are some different actions that appear. It has more activity MU-opioid agonist, but its serotonin reuptake inhibition drops. O-desmethyl tramadol also has a higher affinity for delta and kappa opioid receptors, which may play a role in seizure activity as well.
There's been some debate over the drugs natural occurrence. A French team found the substance in large quantities in the Nauclea latifolia tree. However, it was disproved in the later research suggesting the drug came from cattle who'd been given it. Despite that possibility, other teams have stated it's unlikely to be contamination and they've proposed possible biosynthetic pathways for tramadol.
The drug was synthesized in Germany in 1962. It was made by Grunenthal, a German pharmaceutical company, which hoped to create an opioid that has less respiratory depression and other negative effects.
Tramadol was then sold by Grunenthal under the name Tramal beginning in 1977. Those sales occurred in West Germany and it took quite a while for the drug to reach the US.
The FDA approved tramadol in March 1995 and it was not initially scheduled. But in 2014 it became a schedule for the drug in the US.
A light oral dose is 50 to 100mg; a common dose is 100 to 200 mg; a strong dose is 200-300mg. Due to personal variation, it's wise to use a low dose to see how you respond.
You should always check your local laws before ordering or using Tramadol! It's illegal in the US and it's also illegal in some other countries including Sweden, the UK, and Australia.
Respiratory depression and constipation occur less with tramadol than with other opioids. But the drug isn't entirely safe: deaths have still occurred. Long-term use likely comes with some negative effects and the drug's ability to lower your seizure threshold is a real turn.
Many of the deaths on record come from combining it with other drugs such as alcohol. But there are instances of it being the primary or sole factor in a person's death.
Tramadol is often combined with acetaminophen such as an Ultracet, which makes the drug a bit more dangerous at high doses. Someone with no tolerance using a normal amount of tramadol is fine in this regard. But regular or high-dose usage could expose you to too much acetaminophen putting your liver at risk. It is best to use products that only contain Tramadol.
It does lower your seizure threshold significantly, especially with high doses over 300 milligrams. This effect will be potentiated by other drugs that increase your risk. And if you have a history of seizures, it's best to avoid the drug.
The seizure risk over 300 milligrams is notable and it's not affected by tolerance like some of the other effects. As a result, even if you build a tolerance to its recreational effects and are, therefore, using higher amounts you can't easily avoid the higher seizure risk. Ideally, you won't end up in a situation where you're using that much.
The exact fatal amount isn't known, but doses over 400 milligrams in those without a tolerance could be fatal. Doses within the normal range appear to be acutely safe for healthy people.
Long-term use can come with negative effects such as impaired memory and mood disorders.
Tramadol should not be combined with many drugs. You should especially avoid SSRIs, MAOIs, tricyclic antidepressants and other drugs that influence serotonin levels. MDMA, and amphetamines and even psychedelics aren't good combinations either. And other depressants like opioids, alcohol, and benzodiazepine are best avoided.
Tolerance to Tramadol builds quickly, especially with daily use. The withdrawal comes with a lot of the same effect seen with other opioids such as insomnia, flu-like symptoms, muscle cramps, body temperature, fluctuations, and nausea.
An overdose of Tramadol can cause a seizure, respiratory arrest, hypotension, bradycardia, and death.
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